Lizire I.V.
LEZIRE I.V. is an intravenous infusion containing Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, combined with Sodium Chloride as a diluent. It is used for the treatment of various bacterial infections, particularly in patients who are unable to take oral antibiotics or in cases where rapid and effective treatment is necessary.
- Recommended Usage
Indications
LEZIRE I.V. is used for the treatment of moderate to severe bacterial infections, including:
- Respiratory Tract Infections:
- Pneumonia (community-acquired and hospital-acquired)
- Chronic bronchitis
- Sinusitis
- Urinary Tract Infections:
- Acute pyelonephritis
- Cystitis
- Skin and Soft Tissue Infections
- Bone and Joint Infections
- Intra-abdominal Infections
- Gastrointestinal Infections (e.g., bacterial gastroenteritis)
- Bacterial prostatitis
Levofloxacin is effective against a broad range of Gram-positive and Gram-negative bacteria, as well as atypical pathogens.
Dosage and Administration
Route of Administration: Intravenous infusion.
Typical Dose for Adults:
- General Infections: 500mg of Levofloxacin (in combination with 900mg of Sodium Chloride) administered once daily via intravenous infusion.
- Severe Infections: The dose may be increased to 750mg to 1g once daily, depending on the severity and type of infection.
- Duration of Therapy: Generally ranges from 5 to 14 days, depending on the infection's type and severity.
- Administration: Infuse the medication over a period of 60-90 minutes. Do not administer as a rapid IV push or bolus to avoid adverse effects.
Note: The infusion should be administered under the supervision of a healthcare provider, and patients with renal impairment may require dosage adjustments.
Precautions
Hypersensitivity: Avoid in patients with known hypersensitivity to Levofloxacin, other quinolones, or any component of the infusion.
Tendinitis and Tendon Rupture: Use with caution in patients over 60 years of age, patients on corticosteroids, and those with a history of tendon problems.
QT Interval Prolongation: Levofloxacin may prolong the QT interval; it should be used cautiously in patients with a history of arrhythmia or other heart conditions.
Renal Impairment: Adjust dosage in patients with renal dysfunction. Severe renal impairment may require further reductions in dose.
Pregnancy and Breastfeeding: Levofloxacin should be used during pregnancy only if the benefits outweigh the risks. It is excreted in breast milk and should be used with caution during breastfeeding.
Seizure Risk: Use with caution in patients with a history of seizures or central nervous system disorders.
