Controlled Release Sodium Valproate 200mg Valproic Acid 87mg Tablet
Controlled Release Sodium Valproate 200mg is a formulation of valproic acid (active ingredient) designed for slow and controlled release. This means that the medication is released into the body gradually over time, allowing for stable blood levels and consistent therapeutic effects.
Each 200mg tablet contains 87mg of valproic acid, the active form that exerts its anticonvulsant and mood-stabilizing effects.
Valproic acid is primarily used to treat seizures, bipolar disorder, and migraine prophylaxis.
- Recommended Usage
Indications
- Epilepsy (Seizure Disorders): Effective in the treatment of a range of seizures, including generalized tonic-clonic seizures, absence seizures, and partial seizures.
- Bipolar Disorder: Used for managing acute mania and for long-term mood stabilization in patients with bipolar disorder.
- Migraine Prophylaxis: Prevents migraines by reducing their frequency and severity in patients prone to frequent attacks.
Dosage and Administration
Starting Dose: Common starting dose is 200 mg once daily, typically taken in the evening to minimize side effects like drowsiness.
Dose Adjustment: The dose may be gradually increased, depending on the clinical response and tolerability, typically ranging from 400 mg to 2000 mg daily (divided into 1-2 doses).
Administration: Take the tablet whole, with or without food. Do not chew or crush the tablet to maintain its controlled-release properties.
Precautions
Liver Function: Liver toxicity is a potential risk, particularly during the first few months of treatment. Regular monitoring of liver function (via blood tests) is recommended. Discontinue use if signs of liver damage (yellowing of skin/eyes, dark urine) appear.
Pancreatitis: Pancreatitis (inflammation of the pancreas) is a rare but serious side effect. Symptoms such as severe abdominal pain, nausea, or vomiting require immediate medical attention.
Pregnancy: Valproic acid is associated with birth defects, including neural tube defects (e.g., spina bifida). It should be used during pregnancy only if no safer alternatives are available, and effective contraception should be used during treatment.
Blood Disorders: Regular monitoring for low platelet count (thrombocytopenia), low white blood cells (leukopenia), and other blood disorders is essential during treatment.
CNS Effects: Drowsiness, sedation, dizziness, and cognitive impairment can occur. Use caution when performing tasks requiring mental alertness, such as driving or operating heavy machinery.
