• Customer Care : (+91) 98240 42701

Controlled Release Sodium Valproate 333mg Valproic Acid 145mg Tablet

Controlled Release Sodium Valproate is a formulation designed to release the active ingredient valproic acid slowly over time, allowing for consistent blood levels and improved symptom control with fewer doses.

The tablet contains 333 mg of sodium valproate, which is equivalent to 145 mg of valproic acid, the active form responsible for its therapeutic effects.

Valproic acid is a medication primarily used for the management of seizure disorders, bipolar disorder, and migraine prevention.

  • Recommended Usage
Indications
  • Epilepsy (Seizure Disorders): Valproic acid is effective for treating a range of seizures, including generalized tonic-clonic seizures, absence seizures, and partial seizures.
  • Bipolar Disorder: Used for the treatment of mania in bipolar disorder and as a mood stabilizer to help prevent further manic episodes.
  • Migraine Prophylaxis: Valproic acid can help prevent migraines, reducing both the frequency and severity of attacks.
Dosage and Administration

Starting Dose: The typical starting dose is 333 mg once daily, with the option to gradually increase depending on individual response.

Titration: The dose may be increased in increments, generally up to 1000 mg to 2000 mg daily, depending on the condition being treated and the response to therapy.

Administration: The tablet should be swallowed whole with plenty of water, and it can be taken with or without food. Do not chew or crush the tablet as it may affect the controlled release properties.

Precautions

Liver Function: Liver toxicity is a potential risk, particularly during the first 6 months of therapy. Liver function tests should be done regularly. Signs of liver damage include yellowing of the skin or eyes (jaundice) and dark urine.

Pancreatitis: There is a risk of pancreatitis (inflammation of the pancreas), which can be severe and life-threatening. Seek immediate medical attention for severe abdominal pain, nausea, or vomiting.

Pregnancy: Valproic acid is contraindicated during pregnancy due to its teratogenic effects, particularly its association with neural tube defects. It should only be used during pregnancy if no other options are available, and effective contraception should be used.

Blood Disorders: Valproic acid can cause blood-related issues, such as thrombocytopenia (low platelets) or leukopenia (low white blood cells). Regular blood tests are required to monitor for these conditions.

CNS Side Effects: Valproic acid may cause sedation, drowsiness, dizziness, and cognitive impairment. Use caution when performing tasks that require mental alertness (e.g., driving).

whatsapp