Dosage and Administration
Starting Dose: The typical starting dose is 333 mg once daily, with the option to gradually increase depending on individual response.
Titration: The dose may be increased in increments, generally up to 1000 mg to 2000 mg daily, depending on the condition being treated and the response to therapy.
Administration: The tablet should be swallowed whole with plenty of water, and it can be taken with or without food. Do not chew or crush the tablet as it may affect the controlled release properties.
Precautions
Liver Function: Liver toxicity is a potential risk, particularly during the first 6 months of therapy. Liver function tests should be done regularly. Signs of liver damage include yellowing of the skin or eyes (jaundice) and dark urine.
Pancreatitis: There is a risk of pancreatitis (inflammation of the pancreas), which can be severe and life-threatening. Seek immediate medical attention for severe abdominal pain, nausea, or vomiting.
Pregnancy: Valproic acid is contraindicated during pregnancy due to its teratogenic effects, particularly its association with neural tube defects. It should only be used during pregnancy if no other options are available, and effective contraception should be used.
Blood Disorders: Valproic acid can cause blood-related issues, such as thrombocytopenia (low platelets) or leukopenia (low white blood cells). Regular blood tests are required to monitor for these conditions.
CNS Side Effects: Valproic acid may cause sedation, drowsiness, dizziness, and cognitive impairment. Use caution when performing tasks that require mental alertness (e.g., driving).