Nimera-P Tab
This combination tablet contains Nimesulide and Paracetamol (Acetaminophen), two active ingredients that work together to relieve pain and reduce fever.
- Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain, and fever by inhibiting the COX-2 enzyme, which is involved in the production of prostaglandins that mediate pain and inflammation.
- Paracetamol (Acetaminophen) is an analgesic (pain reliever) and antipyretic (fever reducer) that works by inhibiting a different pathway in the brain that helps control pain and temperature.
- Recommended Usage
Indications
This combination tablet is commonly used for the treatment of:
Pain relief from conditions such as:
Headaches
Toothaches
Musculoskeletal pain (e.g., back pain, muscle aches)
Osteoarthritis or rheumatoid arthritis pain
Dysmenorrhea (menstrual cramps)
Post-surgical or post-injury pain
Fever associated with various conditions (e.g., infections, flu, or common colds)
Dosage and Administration
Typical Dosage: The usual dosage is 1 tablet (100 mg Nimesulide + 500 mg Paracetamol) twice daily, preferably after meals.
The tablet should be taken with a full glass of water.
It is important to follow the prescribed dose and avoid exceeding the recommended daily dose.
Maximum Dosage: Do not exceed 2 tablets per day (200 mg Nimesulide and 1000 mg Paracetamol) unless instructed by a healthcare provider.
Duration: This medication is usually prescribed for short-term use (e.g., for 5-7 days) to manage acute pain or fever. Long-term use should be avoided due to potential risks such as liver damage (from Paracetamol) or gastrointestinal issues (from Nimesulide).
Precautions
Liver Function: Paracetamol can cause liver damage if taken in excessive amounts or for prolonged periods. Nimesulide can also affect liver function, so people with liver disease or a history of liver problems should avoid this combination or use it under close medical supervision.
Kidney Function: Both Nimesulide and Paracetamol can impact kidney function, particularly with prolonged use. Use with caution in patients with kidney disease.
Gastrointestinal Risk: Nimesulide, like other NSAIDs, may cause stomach irritation, ulcers, or gastrointestinal bleeding. It should be used with caution in individuals with a history of stomach ulcers, gastrointestinal bleeding, or other gastrointestinal disorders.
Cardiovascular Risk: Nimesulide may increase the risk of heart attack or stroke, especially when used long-term or in high doses. It should be used with caution in people with cardiovascular disease or hypertension.
Pregnancy & Breastfeeding: This medication should generally be avoided during the third trimester of pregnancy and should only be used during the first and second trimesters if absolutely necessary, under medical supervision. It is also advisable to consult a doctor before using it while breastfeeding.
Alcohol: Avoid alcohol consumption while using this medication, as it increases the risk of liver damage (especially with Paracetamol).
