Olanzapine Rapidly Dissolving Tablet 10mg
- Class: Atypical (second-generation) antipsychotic.
- Mechanism of Action: Olanzapine works by balancing the levels of certain neurotransmitters in the brain, primarily dopamine and serotonin, which helps reduce symptoms of psychosis and mood disorders.
- Formulation: The rapidly dissolving tablet form (often referred to as Zyprexa Zydis) dissolves quickly in the mouth, making it easier for patients who have difficulty swallowing tablets.
- Recommended Usage
Indications
Schizophrenia: Used for treating acute and chronic episodes of schizophrenia.
Bipolar Disorder: Used to treat manic episodes in bipolar disorder, both in acute treatment and as part of maintenance therapy.
Acute Agitation: Sometimes used for agitated patients with schizophrenia or bipolar disorder.
Off-label uses: May be prescribed for treatment-resistant depression, anxiety disorders, and certain neurological disorders.
Dosage and Administration
Starting Dose: Typically, 5–10 mg once daily for schizophrenia and bipolar mania.
Titration: The dose may be adjusted depending on response, with a typical range between 5–20 mg per day.
Administration:
o The rapidly dissolving tablet should be placed on the tongue and allowed to dissolve without the need for water.
o Taken once daily, usually in the evening due to its sedative effects.
o It can be taken with or without food.
Precautions
Pregnancy: Use with caution during pregnancy; it’s classified as Category C. Weigh risks vs. benefits for pregnant women.
Breastfeeding: Olanzapine passes into breast milk; breastfeeding is generally not recommended during treatment.
Elderly: Increased risk of side effects such as sedation, dizziness, and orthostatic hypotension (low blood pressure when standing).
Liver and Kidney Disease: Caution in patients with liver or kidney impairment; dose adjustments may be needed.
Metabolic Changes: Olanzapine can lead to weight gain, diabetes, and increased cholesterol or triglycerides, so metabolic monitoring is advised.
Cardiac Issues: Olanzapine can affect heart rhythm, so caution is needed in patients with cardiovascular disease or those at risk for arrhythmias.
