Olanzapine Rapidly Dissolving Tablet 2.5mg
- Class: Atypical (second-generation) antipsychotic.
- Mechanism of Action: Olanzapine works by modulating the activity of dopamine and serotonin receptors in the brain, helping to reduce psychotic symptoms and mood instability.
- Recommended Usage
Indications
Schizophrenia: For the treatment of acute and chronic episodes of schizophrenia.
Bipolar Disorder: Used for the acute treatment of manic or mixed episodes associated with bipolar disorder.
Acute Agitation: Can be used for managing agitation in patients with schizophrenia or bipolar disorder.
Off-label Uses: Occasionally prescribed for treatment-resistant depression, anxiety disorders, or insomnia.
Dosage and Administration
Starting Dose: Typically, 2.5 mg to 5 mg per day for schizophrenia and bipolar disorder. The dose is often adjusted based on clinical response.
Typical Dose Range: 5 mg to 20 mg per day, depending on the severity of the condition and response to treatment.
Administration:
o The rapidly dissolving tablet should be placed directly on the tongue and allowed to dissolve without water.
o Once daily administration, usually in the evening due to its sedative effects.
o Can be taken with or without food.
Precautions
Pregnancy: Classified as Category C, meaning it should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Breastfeeding: Olanzapine passes into breast milk, and breastfeeding is generally not recommended during treatment.
Elderly: Elderly patients may be more sensitive to side effects, particularly sedation, hypotension, and movement disorders.
Liver/Kidney Disease: Caution in patients with liver or kidney impairment; dosing adjustments may be needed.
Metabolic Effects: Olanzapine can cause significant weight gain, changes in blood sugar (hyperglycemia), and lipid abnormalities, so monitoring for diabetes and hyperlipidemia is important.
Cardiovascular Risk: Caution in patients with heart disease, as Olanzapine can cause orthostatic hypotension (drop in blood pressure when standing up) and may affect heart rhythms.
