Panvas-40 inj.

Indications

PANVAS-40 Inj. is used to treat conditions associated with acid overproduction, including:

• Gastroesophageal Reflux Disease (GERD): For the treatment of erosive esophagitis caused by GERD.
• Peptic Ulcers: In the management of peptic ulcers and for the prevention of recurrence.
• Zollinger-Ellison Syndrome: A condition where the stomach produces excess acid.
• Stress Ulcer Prophylaxis: In critically ill patients, especially those in intensive care units (ICU), to prevent stress-related mucosal damage.

Dosage and Administration

Route of Administration:

Intravenous (IV) injection.

Typical Dose for Adults:

- For GERD and Peptic Ulcers: 40 mg administered once daily via IV injection, typically for 7 to 14 days, depending on the condition and response.

- For Zollinger-Ellison Syndrome: The dose may be higher, typically starting at 80 mg per day, divided into 2 doses. Adjustments depend on the patient's response.

- Stress Ulcer Prophylaxis: 40 mg once daily.

Administration:

- IV Infusion: The drug should be administered via slow intravenous infusion, typically over 2 to 15 minutes depending on the clinical condition.

- Dosage Adjustment: For patients with liver impairment, the dose may be reduced, and regular monitoring is recommended.

- Note: Dose adjustments may be needed for elderly patients or those with hepatic impairment.

Precautions

Hypersensitivity: Avoid in patients with a known hypersensitivity to Pantoprazole or any other PPIs.

Severe Hepatic Impairment: Pantoprazole should be used cautiously in patients with severe liver disease; dose adjustments may be required.

Long-Term Use: Long-term use (beyond 8 weeks) should be done under medical supervision, as it may increase the risk of bone fractures, vitamin B12 deficiency, and gastrointestinal infections.

Pregnancy and Breastfeeding: Pantoprazole is classified as Category B for pregnancy, meaning it should be used only when clearly necessary. It is excreted in breast milk, so caution should be used during breastfeeding.

Drug Interactions: Pantoprazole can interact with other medications (e.g., warfarin, methotrexate, or clopidogrel), and dosing may need to be adjusted in these cases.

Benefits

Effective Acid Suppression: Pantoprazole works by inhibiting the proton pump in the stomach, reducing acid secretion and providing relief from symptoms associated with acid reflux and ulcers.

Fast-Acting: Provides rapid relief, especially in patients who need immediate acid suppression, such as those with severe GERD or stress ulcers.

Convenient IV Formulation: The IV route is ideal for patients who are unable to take oral medications or require immediate treatment in a hospital setting.

Minimal Side Effects: Generally well-tolerated with a low incidence of side effects when used as directed.

Short-Term Treatment Option: Useful in short-term management of acute conditions, particularly in hospitalized or critically ill patients.