Serazip-D
This combination tablet contains three active ingredients: Serratiopeptidase, Diclofenac Potassium, and Paracetamol, each contributing to the reduction of pain, inflammation, and swelling. The combination is used to treat a variety of conditions involving pain and inflammation.
- Serratiopeptidase (15 mg): A proteolytic enzyme that helps in breaking down dead or damaged tissue, thus reducing inflammation and promoting healing. It also helps reduce swelling and pain.
- Diclofenac Potassium (50 mg): A nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting the cyclooxygenase (COX) enzyme, which is involved in the production of prostaglandins.
- Paracetamol (325 mg): A common analgesic (pain reliever) and antipyretic (fever reducer), it works by inhibiting the production of prostaglandins in the brain, providing pain relief and lowering fever.
- Recommended Usage
Indications
This combination tablet is commonly used to manage:
Acute pain from conditions such as:
o Headaches, toothaches, or muscle pain
o Back pain, joint pain, post-surgical pain, or injury-related pain
o Dysmenorrhea (painful menstruation)
Inflammation associated with:
o Arthritis (osteoarthritis, rheumatoid arthritis)
o Soft tissue injuries (e.g., sprains, strains)
Fever reduction, especially in conditions like infections or the common cold.
Dosage and Administration
Usual Dosage: The typical recommended dose is 1 tablet taken once or twice daily, depending on the severity of the condition and your healthcare provider's instructions.
o It should be taken after meals to minimize the risk of stomach irritation.
o The tablet should be swallowed whole with water, not chewed or crushed.
Maximum Dosage: The usual maximum dose is 2 tablets per day (100 mg Diclofenac, 650 mg Paracetamol), but the exact dosage will depend on your healthcare provider’s recommendation.
Duration: This medication is typically prescribed for short-term use (e.g., for 5-7 days) to manage acute pain or inflammation. Long-term use should be under medical supervision due to potential risks associated with the active ingredients.
Precautions
Liver and Kidney Function:
Paracetamol can cause liver damage if overused, especially in those with existing liver disease.
Diclofenac can affect kidney function, especially with prolonged use. Use with caution in individuals with pre-existing kidney problems.
Gastrointestinal Risk: Diclofenac (like all NSAIDs) may irritate the stomach lining, leading to ulcers or bleeding. It should be used with caution in individuals with a history of gastric ulcers or gastrointestinal bleeding.
Heart Disease: NSAIDs such as Diclofenac may increase the risk of cardiovascular events, including heart attack and stroke, particularly when used long-term. Use with caution in individuals with heart disease or high blood pressure.
Allergic Reactions: Some people may experience allergic reactions, especially to Diclofenac or Paracetamol. Symptoms may include rash, itching, or swelling.
Pregnancy and Breastfeeding:
o Diclofenac should generally be avoided during the third trimester of pregnancy, and should be used cautiously in the first and second trimesters under the supervision of a doctor.
o Paracetamol is generally considered safe during pregnancy but should still be used at the lowest effective dose for the shortest duration. Consult a healthcare provider before using this medication during pregnancy or breastfeeding.
Elderly: Elderly individuals may be more prone to the side effects of Diclofenac, particularly gastrointestinal bleeding and kidney issues.
