Clopidogrel bisulfate is an antiplatelet medication that helps prevent blood clots, reducing the risk of heart attacks, strokes, and other cardiovascular events in people with certain conditions. It is often prescribed to people with coronary artery disease, peripheral artery disease, or those who have had a recent stroke or heart attack.
1. Bleeding Risk: Since clopidogrel works by preventing platelets from sticking together, it increases the risk of bleeding. Care should be taken when using it in patients with:
CYP2C19 genetic variations: Some people have genetic variants of the CYP2C19 enzyme, which can affect how well clopidogrel works. These genetic variations may reduce its effectiveness, so genetic testing may be recommended in some cases.
Liver Disease: Patients with liver impairment should be monitored carefully, as clopidogrel metabolism may be affected.
Drug Interactions: Clopidogrel can interact with various drugs, including:
Contraindications: