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Sitagliptin Phosphate + Metformin HCL

The combination of Sitagliptin Phosphate and Metformin HCL is widely used in the management of type 2 diabetes mellitus. Sitagliptin is a DPP-4 inhibitor that enhances the body’s natural ability to regulate blood sugar by increasing insulin release and decreasing glucagon levels. Metformin is a biguanide that works by reducing hepatic glucose production and improving insulin sensitivity. Together, they provide effective glycemic control.

  • Recommended Usage
Indications:
  • Management of type 2 diabetes mellitus in adults.
  • As an adjunct to diet and exercise to improve glycemic control.
  • May be used as monotherapy or in combination with other antidiabetic medications.
Dosage and Administration:
  • Typically administered orally twice daily with meals to reduce gastrointestinal side effects.
  • Dosage varies based on patient needs:
    • Common doses: Sitagliptin 50mg + Metformin 500mg/850mg/1000mg.
    • Adjustments may be made depending on renal function or glycemic control.
  • Maximum daily dose should not exceed Sitagliptin 100mg and Metformin 2000mg.
Precautions:
  • Contraindicated in patients with severe renal impairment, metabolic acidosis, or hypersensitivity to any component.
  • Use with caution in elderly patients or those with liver disease.
  • Discontinue immediately if lactic acidosis is suspected.
  • Regular monitoring of renal function is recommended.
Key Benefits:
  • Dual Action: Combines two complementary mechanisms to effectively manage blood glucose levels.
  • Improved Glycemic Control: Helps reduce both fasting and postprandial blood glucose.
  • Weight Neutral: Unlike other diabetes medications, this combination is generally weight neutral.
  • Convenience: Simplifies treatment with a single tablet regimen.
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